Vast potentials for potentiation and conservation

Here is some extreme education piece... now both ibogaine (12-Methoxyibogamine) and Noribogaine (12-Hydroxyibogamine) both seem to be able to be cycle because they are amines i am currently looking up the receptors ibogaine alone hits, wile wiki lists the following for Noribogaine: "Noribogaine is most potent as a serotonin reuptake inhibitor and acts as a moderate κ- and weak µ-opioid receptor full agonist" the serotonin reuptake inhibitor part means temporarily during its effects the serotonin system is somewhat suppressed but upon the effect wearing off their is a permanent increase in the reuptake of serotonin, that is only reversed with continued over-activation of that system most usually by drugs of abuse. one of the iboga effects are hallucinations from 5HT2A agonism, this is the primary receptor most psychedelics effect, downstream (downstream means activating this causes the activation of) this agonizes dopamine 2 receptor (D2), some compounds don't start with 5HT2A at all and instead directly effect D2 like salvia and cannabis, the primary effects of cannabis are D2 agonism, hard drugs like meth and cocaine the dream states these can cause are also caused by D2 agonism. lsd has a D2 agonism component. now iboga is good in chronic micro doses (multiple reasons this is just one) because its kappa agonism increases the amount of D2 receptors in the brain, so that its 5HT2A agonism has more D2 receptors to flow into downstream. the kappa opiod agonist part means you will get dynorphin, and your D2 receptors will be upregualted meaning increase the amount of receptors on the cell (addiction downregulates, anti-addictives upregulate) dynorphin is the primary feeling of dread or loathing or dysphoria produced by drug withdrawal, intense exercise also produces dynorphin release. dynorphin itself agonizes kappa receptors. agonizing kappa receptors also releases dynorphin. regardless of the means of activation agonizing kappa receptor reverses addiction in many key areas, it does not fix it, it pushes the bar in the right direction, in the same way abstaining from drugs for long periods would, so its kind of like speeding up time, agonizing this receptor as far as drug withdrawal is concerned because you can concentrate strong withdrawal of the drug into a short period of time and be done with it instead of dragging the dread out for weeks and months. its effects on µ-opioid receptor are weaker than for kappa this is good, this receptor will give it a little bit higher of a serotonin phase in the beginning, it also makes this compound very useful for pain treatment and addiction treatment, because the NMDA antagonism makes its µ-opioid agonism non-tolerance creating, and the kappa agonism reverses the tolerance the user already had before ingestion. the more CYP2D6 enzyme present in the stomach the less ibogaine you will get and the more Noribogaine you will get below is a list of inhibitors for that enzyme witch will cause ibogaine to be active alone taking much longer for the enzyme to recover and turn ibogaine into Noribogaine. i will post more when i find out what ibogaine does alone. i realize all this sounds fairly complicated at first, but you have to understand i am no student in any university or college, the psychedelics lead me to interest in how ABSOLUTELY everything effects the way i feel and my health and i take it as a form of creative expression to find out these things(there is no right or wrong just learning), once you truly understand the connectivity of all the systems in the brain and body and have a good relationship with psychedelics you truly hold the keys to the the mysteries of nature, the physical design and structure of the physical body and its micro systems, reflects perfectly the structure of the spiritual bodies and realms and their structure. the design of the structure comes from the same source. POTENT CYP2D6 INHIBITORS Cannabidiol (from Cannabis) Echinacea purpurea Goldenseal Pomegranate juice (Punica granatum): 1 cup Pummelo Saint John’s Wort (high dose) Starfruit juice White grapefruit juice: 2 cups MODERATE CYP2D6 INHIBITORS Black pepper: 5 grams (ingest the solids, it's an ineffective inhibitor as tea) Calamus EO: 3 drops Kava Pi. cubeba Quercetin Zingiber aromaticum WEAK CYP2D6 INHIBITORS Alpha-asarone (found in Calamus EO) Black cohosh Capsaicin (found in cayenne pepper, habanero peppers, etc.) Cayenne pepper Common sage Cryptotanshinone Curcuma heyneana Curcumin German chamomile EO Ginkgo biloba Habanero pepper Milk Thistle Safrole Tanshinone I Turmeric Modify message

I'm breaking this into different posts so people can at least get a taste.  It is extremely hard to digest all this info... i have a high level wizard friend who can distinguish most of the dopamine receptors by the color of hallucinations they cause. personally the only thing i can think of that is similar to that is from dosing yin on left and yang on right half of body i can feel dopaminergics or serotonergics very distinctly when taken now. yin = serotonin yang = dopamine also if you take these you will get more Noribogaine effects and less ibogaine effects: CYP2D6 INDUCERS Valerian root Valerian root EO: 2-5 drops i am still looking up the effects of ibogaine alone without noribogaine will post when found. __________________________________________ THIS ONE IS VERY IMPORTANT... "I'm considering now posting whatever you write on the iboga forum as this is some of the most advanced Iboga infor I have come across" permission granted "So are you saying rather than doing the "Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation" cycling for Iboga instead one would utilize the CYP2D6 INHIBITORS?" i am saying combining for iboga to get Noribogaine to cycle: piperidine (black pepper tea or L-lysine) ALDH inhibitors (grocery store natural almond and star anise extracts) (or just tea made from whole star anises) and then an CYP2D6 INDUCER like valerian, it could take anywhere from 30 minutes to over an hour after taking valerian for its induction to kick in. so the timing would be for noribogaine: pepper tea without solids (or l-lysine) and valerian at the same time 45 minutes later 20-40 drops each of natural star anise extract and almond extract from grocery store, sewing needle pokes small enough holes for drops in the foil seal, if put in gel caps with olive oil and taken followed right after by half peanut butter sandwich it is infinitely more enjoyable. or if your lazy you could eat 20 drops of each and apply 10+ drops to the skin above the liver and or along the meridians connected with the stomach and intestines and such, taking a caffeine tablet with these extracts at the same time will boost the ALDH inhibition very strongly. 15 minutes later take ibogaine (possibly best if taken in gel caps, mixed with olive oil might help as well, and with very small bite of peanut butter sandwich) if one cannot get valerian, they could take any of the short lasting INHIBITORS listed, the day before taking piperidine and ALDH inhibitors, and the next day after taking the short lasting inhibitors they will have long worn off with a high probability of the body slightly inducing the enzyme upon recovery from the inhibitor, you could do this by combining inhibitors under "weak" or "moderate" in extremely small doses the day before trying to cycle Noribogaine. ibogaine without noribogaine: if you wanted to cycle ibogaine alone without noribogaine effects (or very little noribogaine) you would do the same thing but make sure not to take valerian and instead ON the day of the cycling you would take strong CYP2D6 inhibitors at the same time as the ALDH inhibitors, in both set-ups you take the piperidine or dimethylamine 45 minutes before the ALDH inhibitors. "Many seek the Noribogaine effects as this is filled with positive bliss.  If you can hone this one out...BOOM BUHM!  " do you mean what needs to be done to get only Noribogaine? simple, dose valerian an hour to an hour and a half before iboga, if you cannot get your hands on valerian, then the day beforehand dose a combination of short lasting weak-moderate strength inhibitors from the list, then the next day when you take the iboga, you take it EXACTLY 15 minutes after the time you took the inhibitors the day prior. your bodies enzyme runs on a tight schedule and if you inhibit or induce something they get written down in the schedule and your body expects to be repeating that act at the same time everyday this becomes more and more strong the more days on the EXACT same timing you take an inhibitor or inducer. _______________________________________________________________ wait.......... are their native groups that micro dose iboga daily?... if so i have some insights to share about what they are causing to happen by doing this. if you dose iboga for many days in a row and then stop 1-2 days before a higher dose or flood, you will get strong Noribogaine effects, because ibogaine inhibits CYP2D6 when the enzyme breaks it down, if you do this the same time everyday, then the body eventually starts to retaliate by overproducing the enzyme to compensate, so the first few experiences are mainly ibogaine and the later experiences should all be highly noribogaine. "No one else has done this I suppose?" untouched soil friend, tread lightly (:

I am blown away by this thread.  First off, kudos to you both for thinking socially and environmentally responsible in terms of our common sacrament being officially endangered.  I studied biopsych, a little neurochem, but a lot of this stuff is still foreign to me.  I almost want to take a class on brain chemistry and addiction, etc.  One thing to be noted is Valerian root is not recommended with benzos, moderate interaction there I believe.  Please keep this thread going.  It think it's value is underrated by many.  It would be great to get some of this information tested, and some more anecdotal evidence written for the layman so everyone can see what innovation this topic really is.

Yeah... Wow, consider me blown away as well.  So this has been tested?  How much do you think it may potentiate Iboga?  Very curious, hope to see more info.

Well basically Peaceful Warrior and I made a pact/allegience to accomplish this task.  So he is just now getting started in the experimental cycling phase.  I would have started but got enthralled by something else and also was a bit scared.  Being that Peaceful Warrior is a bit more of a maverick and use to testing the limits like this it turns out he is the perfect on for the job.  First tests as of 2 days ago are proving successful.  Over on the Kambo forum he was to do another test "Papa(Iboga)Kambo Papa(Iboga)" while cycling and then report back but have yet to hear from him.  To say I am eagerly awaiting the results is quite the understatement.  This dudes is a freaking genius.  Young too.  A prodigy like no other, I think he might save the universe from destruction...kind of joking kind of not.  I'm basically waiting for his initial results and him testing the waters before I dive in.  Also I am on a different quest as of now so it might be a while, once his results come back (pretty damn sure it's gonna work) I think nearly the whole community might jump on board.  I mean if you end up only needing 1gr of Iboga to have Noribogaine rolling in your system, you'd be a damn fool not to cycle with Iboga.

He's a total maverick freakazoid genius from planet infinity, so no medical experts are involved.  I think Kambo by it's nature has one on the cutting edge so a yes in that direction.  That being said part of our agreement is that he has to share his findings.  You would not believe some of the stuff he has PM'd me.  Leaves me utterly speechless what this being of light (Peaceful Warrior) is doing on a daily basis.  He makes me feel like a slacker and makes me motivated to step up my game.  Will certainly share whatever he gives me permission to.  Basically he was able to get off on only sniffing Kambo without inhaling it and tasting the granules of Iboga one by one.  So if I can get him to be more explicit and sway it out of him, I will be more than happy to share whatever he allows.  He's very in love with Iboga after working with it for only 2 days is the essence of the cycling so far.  He feels it can cure just about everything, so much so he wanted to play it rather hush for it's sacred nature to not be overly revealed.  Sometimes he leaves me just scratching my head from these PM's feeling like I'm like 50 billion eons behind him.

Total maverick freakazoid geniuses from planet infinity often are the ones that sit at the core/origin of much social evolution.  Look at Einstein.... Anyway, you officially and literally have me hanging on a thread here....I am getting neck cramps from sitting at the edge of seat!

In this formula to get noribogaine to cycle from iboga what form of ibogaine is being used? Is HCL used or usable? This is a fascinating concept for potentiation.

HCL would be optimal but we don't have any.  So I'll be using TA (when I get around to doing it) and Peaceful Warrior will/has used Root Bark.  He got so struck by the sacred nature of Iboga and it's healing properties that now I'm worried he's not gonna share much to the public.  Maybe tomorrow, today was supposed to be a big experiment to find out.

So I decided to give this a try.... I've been taking 1 gram of RB each evening for 4 days. Last night, I took 500mg Lysine with 450mg valerian. Waited 45 mins then took 20 drops of the star anise and 20 drops of the almond extract with some peanut butter on half a slice of bread. Waited 15 mins then took 1 gram RB. On its own, I can just feel a subtle effect of the Iboga at this dose. Didn't notice anything last night but feel a little more under the influence this morning - nothing dramatic and could be due to the stacking effect of MDing or the cycling or both. Maybe I need to take more Lysine? ANy suggestions welcomed - I'll try again tonight with 1000mg lysine unless someone has other suggestions. It would be great to get this working

You'll need to ask Peaceful Warrior, he's not here and I doubt he ever visits Iboga forum.  I'm working intensively with Aya, Rape' snuff and Sananga and currently don't know when I will be able to try.  Iboga has told me to wait for a while before studying his holy tabernacle again.  I'm so sensitive to Iboga though that really I don't need/want it to be that intense so such studies are more for the community at large for me personally.   If others can do so that would be quite beneficial.  If you wouldn't had quite Kambo.me than you could ask him.  But at any length long story short check you PM for his personal e-mail which he checks maybe once per week.

Thanks - I'll see what he thinks. Looks like he hasn't posted in a while. Now that I'm moving around more, I do notice a more stoned effect - its good that I have the day off as i don't think I'd be able to concentrate as well I could yesterday. Understand that your focus is elsewhere.

I heard back from PW - he's going to post an update on his findings soon. I guess it worked better than I thought... I could function just fine yesterday but by the evening, I could really feel the sense of being stoned kicking in - ended up horizontal on the sofa for most of the evening and decided to skip taking a 1 gram dose last night. Feel OK this morning, just experiencing the normal effects of MDing. I told PW that I didn't want to take any chances with this as it's unchartered territory and won't try cycling again until I see his next post on this. He agreed that this was the right thing to do.

Thanks for the Update.  No need for excess on posts or intake.  Bless.